Preheat the oven to 350 degrees and spray a 9 inch loaf pan with cooking spray. Set the pan aside.
In a large bowl whisk together the flour, baking soda, baking powder, cinnamon, salt, nutmeg, and ginger.
In a smaller bowl mix together the pumpkin, sugar, butter, eggs, and vanilla extract. Gently fold the pumpkin mixture into the dry ingredients until just combined.
Pour the batter into the prepared baking dish.
Mix together the butter, brown sugar, flour, and cinnamon with a fork. The mixture will be crumbly. Pour over the top of the bread.
Bake the bread for 55 to 65 minutes or until a toothpick stuck in the center of the bread comes out clean.